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Elevated Plus Maze

Cerca Insights Sdn Bhd
The elevated Plus Maze: - is commonly described as a rodent model of anxiety. It is can be used as a screening test for putative anxiolytic or anxiogenic compounds. The test setting consists of a plus sign shaped platform elevated from the floor with two open and two enclosed arms. Aversion to open spaces translates to a restriction of movement to the enclosed arms in the plus maze. Drugs that increase in the proportion of time spent in the open arms and an increase in the proportion of entries into the open arms are potentially anxiolytic. Benzodiazepines such as valium reduce measures of anxiety in the elevated plus maze.

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