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Out-licensing: "BONAC-ssRNAi : nkRNA® & PnkRNA™” as a synthetic single strand RNA oligomer and a novel class of RNAi platform technology.
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"BONAC-ssRNAi : nkRNA® & PnkRNA™” as a synthetic single strand RNA oligomer and a novel class of RNAi platform technology.

BONAC Corporation
Synthetic single strand RNA oligomer as a novel class of RNAi platform technology with higher biological and chemical stability than canonical siRNAs without any chemical modifications, showing higher in vivo efficacy.

Full description

BONAC-ssRNAi (nkRNA® & PnkRNATM) is synthetic single strand RNA oligomer as a novel class of RNAi platform technology with higher biological and chemical stability than canonical siRNAs without any chemical modifications, showing higher in vivo efficacy.

nkRNA®, a single-stranded RNA composed of nucleotide residues, has the following characteristics:

  • Possible to induce RNAi by introduction of expression-suppression sequences (antisense of siRNA) into the BONAC Platform basic frame (nkRNA). Any sequence of siRNA even miRNA can be mounted.
  • High physicochemical stability, high catabolic enzyme resistance
  • Possible to control the effects of interference
  • Simple production process due to single strand RNA (annealing is unnecessary, etc.)

 

PnkRNATM, in which originally developed amino acid derivative is substituted for the Linker regions of nkRNA®, has the following additional characteristics.

  • Enhancement of the in vivo interference effect
  • Further improved physicochemical stability
  • Significant product cost reduction

BONAC has been also conducting collaborative research with several universities and research institutes for creating new therapies with multiple potential applications in ophthalmology, dermatology, respiratory, oncology etc., using these two platform techniques. In vitro and in vivo data is available for assessment.

  • Summary of advantages of BONAC RNAi therapeutic agents:
  • Higher biological and chemical stability than canonical siRNAs without any chemical modifications
  • High efficacy in different animal models of disease
  • Unique and strong patent status
  • High performance "BONAC EMM amidite", allowing high yield with high quality/purity even a long-strand RNA oligomer
  • Simple manufacturing process with low cost production (ssRNA)
  • Novel isotope labeling technology, providing Pharmacokinetic solution

 

Development status

Preclinical

Patent information

nkRNA®
Patent application 2010-156122 (July 8, 2010)
PCT international patent application : PCT/JP2011/065737 (July 8, 2011)
National phase entry: EP, US (13/254,150), JP (2011-537086)

PnkRNATM
Patent application: 2010-174915 (August 3, 2010)
PCT international patent application : PCT/JP2011/067292 (July 28, 2011)
National phase entry: EP, US (13/254,159), JP (2011-537085)

 

 

Type of business relationship sought

Licensing of the company's platform technology including the collaborative research agreement.

Patent number

Under Application

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Licensing contact

Kazunori Yoshikawa
Managing Director & CFO

Contact directly

Company details

BONAC Corporation

Bonac Corporation of Japan is a research oriented company with a focus in nucleic acid chemistry. Bonac has developed a novel proprietary platform technology for RNAi.

View profile
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